All that brains can know has been synthesized withinthemselves, in the form of hypotheses about the world

The only patterns that are integrated into the activities of the brain areas to which the sensory cortices transmit their outputs are those patterns they have constructed within themselves…. They are not direct transcriptions or impressions from the environment inside or outside the body. All that brains can know has been synthesized within themselves, in the form of hypotheses about the world. (2000, 90).  – Walter Freeman